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Studies have shown that the metabolite of bilirubin, biliverdin, suppresses NF-B activation caused by TNF-, and overexpression of NF-B stimulated by hbvr causes the cell cycle to halt in phase 1/0

Moreover, the small molecules erastin and sorafenib could block system Xc function, triggering ferroptosis in cancer cells derived from the liver, kidney, and lung (Louandre et al., 2013

Using the common terminology criteria for adverse events (CTCAE - Version 5.0) to evaluate the severity of adverse events of anticancer therapies

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doi:10.1016/S0014-2999(99)00114-4

Danquah A, de Zelicourt A, Colcombet J, Hirt H